The Minnesota Vikings (11-5 in 2015) hit the road in Week 1 to play the Tennessee Titans (3-13 in 2015), making it the seventh time in the past nine years the team as opened as the away team. It is the first time since 2008 the Vikings will take on the Titans in Nashville. Minnesota owns an 8-4 record in the series between the franchises. The Vikings held a 5-3 record on the road during the 2015 season, and the Titans finished last season with 1-7 mark at home.
RB Adrian Peterson looks to defend his 3rd-career rushing title after leading the NFL in 2015 with 1,485 rushing yards.