Twins starter Ervin Santana, who spent his first eight years with the Angels, was tagged with the loss after giving up five runs on 10 hits in five innings.
The Angels got on the board with an Albert Pujols RBI single in the first. Giavotella, coming off his first career four-hit game, delivered a two-run homer in the second and Calhoun added a solo shot in the third, giving him eight on the year. Calhoun then gave the Angels what ended up being a crucial insurance run with an RBI double in the fifth.