The Minnesota Twins open the 2016 season with a day game in Baltimore, a team they beat 7 times out of 7 tries last year. A four game sweep at Camden Yards late last August vaulted the Twins into the playoff race, while also dashing the hopes of the Orioles.
A quirky stat from the 2015 series is that not one, but two Twins each got a win and a save against the Orioles last year, Glen Perkins (not unusual) and Tommy Milone, who started and won a game in July and then got his first-ever save in an extra-inning win (Perkins) in the last meeting between these two teams.