Santana will make his season debut after undergoing surgery on his right middle finger in February. He posted a 3.72 ERA in seven rehab starts in the Minors, but he is expected to be limited to roughly 85 pitches in his debut.
Gaviglio returns to the mound after making the longest start of his career, a 7 2/3-inning outing against the Orioles. He will look for his first win since May 25 against the Phillies.