It was the second walk-off win this season for the Brewers, who beat the Cubs on a wild pitch April 7. Thames' homer, which snuck over the fence in left field over two Padres defenders, was his 19th this season to keep pace with the Nationals' Ryan Zimmerman and the Reds' Joey Votto for the National League lead.
Wil Myers and Hunter Renfroe homered in the Padres' four-run first inning, but Brewers starter Junior Guerra did not allow another hit while working through the end of the sixth.