Middlesbrough make the trip to Deepdale on Saturday afternoon as they look to strength their position in the playoff spots (15:00 GMT).
Boro beat fellow promotion contenders West Bromwich Albion to go three points ahead of the Baggies and into fifth on the table.
While Preston North End have not lost any of their past three league games and earned a point against Middlesbrough in September's reverse fixture.
Preston North End have won each of their last four home league games against Middlesbrough since December 2020, as many victories as across their 18 prior matches at Deepdale combined (D6 L8).