Middlesbrough's caretaker boss Steve Agnew may have Bernardo Espinosa and Rudy Gestede available after injuries.
Adlene Guedioura returns after being cup-tied, but Daniel Ayala, Calum Chambers and George Friend are out.
Paul Pogba misses out for Manchester United because of a hamstring strain, while Daley Blind received a blow to the head against Rostov and is a doubt.
Zlatan Ibrahimovic and Ander Herrera are suspended, but Wayne Rooney, Luke Shaw and Anthony Martial could be fit.
MOTD COMMENTATOR'S NOTES
Guy Mowbray: "With Jose Mourinho stressing that United have 'lots of enemies' this week, it might have been nice for him to catch up with a friend.