Middlesbrough will be without Calum Chambers after the defender suffered a stress fracture to his foot.
Midlfielder Gaston Ramirez is still on the sidelines, but new arrivals Rudy Gestede and Patrick Bamford are in contention to start.
Accrington boss John Coleman has Matty Pearson and Scott Brown suspended for the tie at the Riverside.
Defender Pearson begins a three-match ban, while midfielder Brown serves the second game of his four-match ban.
MATCH FACTS
Head-to-head
- Middlesbrough's only previous match against Accrington Stanley saw them dumped out of the League Cup in August 2013, losing 2-1.