Buffalo has only been at the Division I level since 1997, but they’ve had a number of successful prospects make the league over that time, perhaps most notably Khalil Mack, who went fifth overall to the then-Oakland Raiders in the 2014 NFL Draft.
But UB had some history with the NFL Draft before the late 1990’s. Their first selection actually came in the 1952 NFL Draft, with tackle Les Molnar hearing his name called by the New York Yanks (who would technically play as the Dallas Texans due to the Yanks’ dissolution.)
Buffalo did manage to have one player from their FCS era team drafted in their return to the sport’s top leagues in tackle Ed Ellis, who was selected by the New England Patriots in the 1997 draft, breaking their 33-year gap without a Bull being selected in the draft.