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The 10 biggest college football point-spread upsets

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The Georgia Tech Yellow Jackets kicked off the 2024 college football season with an upset win vs. the Florida State Seminoles.

Check out the 10 biggest college football point-spread upsets over the past 30 years.

1. Howard Bison (+45.5) over UNLV Rebels

Sept. 2, 2017

It's only fitting that the biggest upset in college football history would happen in Las Vegas. For a team to win as 45.