Ohio State has been favored in its past 51 games, the longest such streak in the nation and one that dates back to the 2015 College Football Playoff championship.
That streak will likely end this week.
The sportsbook at Caesars Palace in Las Vegas on Sunday installed the Buckeyes as 3.5-point underdogs against Michigan. Ohio State hosts the Wolverines on Saturday in a showdown that will decide the Big Ten East Division champion.
Barring dramatic line movement this week, the Wolverines will be favored over Ohio State for the first time since 2011, when Michigan knocked off the Buckeyes 40-34 as 8-point favorites.