Moritz Wagner and Derrick Walton Jr. each hit from beyond the arc and Michigan stretched its lead to six at one point before Louisville was able to get a much-needed bucket from Deng Adel.
The Wolverines lead the Cardinals 63-59 with 3:36 left to play.
Wagner is leading the way with 22 points and will be heading to the line when the teams come back from the timeout.
One good shot deserves another
Michigan has come all the way back after taking a brief lead and they are tied with Louisville 55-55 with 6:59 left to play in regulation.