As time expired in the third quarter, Michigan added to its lead on a 2-yard touchdown run from De'Veon Smith.
The scoring drive, which went 52 yards in eight plays, featured a 15-yard pass from Wilton Speight to Jake Butt, whose 1,521 career yards are the best for any Michigan tight end.
Speight, now 19-of-24, has a career-high 362 yards passing.
Up 45-0 after three quarters, Speight's day, along with the rest of the starters, is likely done.
Maryland follows with turnover
With a quarter and change to play, Maryland is running out of time to score.