Purdue has scored the first six points of the second half to extend its lead to 44-30, forcing Michigan to call a timeout.
The 14-point lead is the biggest of the game for the Boilermakers.
Purdue leads Michigan at halftime, 38-30
Both teams cooled off from the field late in the first half, but Purdue managed to pull away and lead Michigan, 38-30, at halftime on Saturday.
Michigan missed its last four and closed the first half 2-for-12, while Purdue was 2 of its last 8.
A.J. Hammons was hard to stop, scoring 15 points on 7-for-10 shooting to lead the Boilermakers Caleb Swanigan added seven points.