Michigan State wound up on the wrong end of NCAA Tournament history Friday. But it's not the first time a No. 2 seed has lost to a No. 15.
Entering this season's tournament, the No. 2 seed had a 117-7 record against the No. 15 seed. So Michigan State's loss is the 8th.
Here's a look at all of them, games which helped make this March Madness.
Michigan State coach Tom Izzo called Friday's 90-81 loss to Conference USA tourney champ Middle Tennessee the most difficult of his career, saying that previously the toughest loss was then-No.