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The San Francisco 49ers running back Isaac Guerendo is dealing with a hamstring injury and is unlikely to play Sunday at the Miami Dolphins, a source told ESPN's Adam Schefter on Thursday.
Guerendo has risen to the top of a 49ers depth chart at the position that has been decimated due to injury this season. Christian McCaffrey, Jordan Mason and Elijah Mitchell all sustained season-ending injuries this season.
The other running backs on the 49ers' 53-man roster are Patrick Taylor Jr.