With Manchester City, Leicester City and a whole host of clubs striving to overtake us at the summit of the table, getting back to winning ways on the road is a must after Sunday's draw with Liverpool.
But the home side have shown resilience recently after a difficult opening few months back in the top flight, and will be out to cause a shock...
HOW TO WATCH
The match at Craven Cottage kicks off at 20:15 GMT on Wednesday and will be broadcast live in the UK on BT Sport 1. You can follow all the action on ManUtd.