It will be the Reds’ second meeting with a Serie A side this season, after dispatching Roma’s Serie A rivals AC Milan in the round of 16.
As we approach the business end of the season, let’s take a look at all the essential info ahead of the game…
HOW CAN I FOLLOW THE MATCH?
The contest kicks off at 20:00 BST on Thursday and will be broadcast live in the UK via BT Sport. You can also follow the action via ManUtd.com and our Official App, where you’ll be able to check the live in-game data through our Match Centre.