The U’s, who currently sit ninth in League Two, have already defeated two Premier League sides on their way to the last eight, and will be keen to make it a hat-trick on their first-ever visit to Old Trafford.
Here’s everything you need to know about the League Two outfit ahead of kick-off…
TEAM NEWS
Forward Courtney Senior is a doubt for the U's after being substituted with a quad injury at half-time during their 2-2 draw against Scunthorpe United on Saturday. The 22-year-old, who has scored three goals so far this season, including one in the Carabao Cup, was replaced by Callum Harriott, although manager John McGreal said he hoped the problem wasn’t as bad as first feared.