Jose Mourinho's men secured a place in the last 16 during the previous round of fixtures, but we can still finish first or second in the group depending on the results on Wednesday evening.
The boss will be hoping for a similar performance to the one his side produced on Saturday, when the Reds cruised to a 4-1 win against Fulham at Old Trafford.
Here’s everything you need to know ahead of the game...
ANY TEAM NEWS?
The Reds could be without several first-team players for Wednesday’s game. Eric Bailly, Luke Shaw and Anthony Martial missed Saturday’s win over Fulham through injury, while Chris Smalling was replaced in the second half with an apparent injury.