The Reds need to respond after the 4-0 loss to Everton on Sunday, but face a City side who are gunning for a second successive title.
A home win could derail those hopes and would strengthen our top-four aspirations, which were boosted over the weekend with all three rivals Arsenal, Chelsea and Tottenham Hotspur dropping points.
Here is what you need to know ahead of the derby...
HOW CAN I FOLLOW THE GAME?
Wednesday's game kicks off at 20:00 BST and will be shown live on Sky Sports in the UK.