Following our triumph over the Blues back in May in the Emirates FA Cup final, and their Premier League success, this bout will be a re-run of that memorable day and the third Manchester derby to occur at Wembley in just over a year.
Our opponents this weekend were defeated in last year's edition of the fixture, that time against Arsenal, on penalties.
Keep scrolling to find out everything you need to know about the upcoming clash...
HOW TO WATCH AND FOLLOW
The season opener is being broadcast live on ITV 1, ITVX, STV and STV Player in the United Kingdom, with kick-off set for 15:00 BST.