Ole Gunnar Solskjaer’s men will be determined to notch a win after two consecutive defeats at home and in Europe.
The Toffees, managed by Carlo Ancelotti, are also seeking to recover from a bump in the road, which has threatened to halt their early-season momentum.
Here’s everything you need to know ahead of this clash between Manchester's Reds and Merseyside's Blues...
LIVE COVERAGE
Kick-off will be at 12:30 GMT on Saturday and fans in the UK can watch events unfold live on BT Sport. Supporters all over the world can also follow our rolling updates on ManUtd.