The Reds will meet the Bluebirds for the first time since a 2-2 draw at the Cardiff City Stadium in November 2013.
This weekend's match is the first of four games in the space of just 11 days over the festive period for United, who will look to return to winning ways after last weekend's 3-1 defeat at Liverpool.
Here's everything you need to know ahead of Saturday's game...
WHAT'S THE TEAM NEWS?
The Reds were boosted by the return of Victor Lindelof as a starter and Anthony Martial as a substitute after injury in last weekend's game at Anfield.