The Reds kicked the new Premier League campaign on a winning note, with a 2-1 victory over Leicester City at Old Trafford last Friday night, and Jose Mourinho's men will be hoping to make it back-to-back wins on Sunday afternoon.
Our match preview is here to get you up to speed ahead of the trip to the south coast...
HOW DID BRIGHTON DO ON THE OPENING DAY?
The Seagulls, who finished 15th last term, were downed by a Roberto Pereyra double last weekend as they lost 2-0 to Watford, in the first game of what is their second successive season in the top flight since earning promotion.