After a closely fought first leg at Old Trafford, it is Luis Suarez's header, that deflected in off Luke Shaw for an own goal, that separates the two sides going into the crucial second tie with Ole Gunnar Solskjaer's squad looking to draw inspiration from last month's staggering turnaround against Paris Saint-Germain to book a place in the semi-finals of the competition.
Here is everything you need to know ahead of this mouthwatering encounter...
HOW CAN I FOLLOW THE GAME?
The match kicks off at 20:00 BST on Tuesday and will be shown on BT Sport in the UK.