Blaugrana coach Xavi reacted to the news during his press conference at the Nou Camp, following the hugely entertaining 2-2 draw on Thursday evening.
Pedri was injured in the closing stages of the first half and early reports suggest he will be sidelined for around a month.
Gavi collected a yellow card for a cynical shirt-pull on Fred as the Brazilian raced away from him in the second half and must serve a one-match suspension in the competition.
After United were forced to play the first leg without Lisandro Martinez and Marcel Sabitzer due to suspension, maybe the tables will be turned a little in Manchester.