Diogo Dalot, Bruno Fernandes and Cristiano Ronaldo all started as Portugal defeated Turkey 3-1 to progress but North Macedonia, rather than Italy, will provide the barrier to a spot in Friday's draw for the big event in Qatar, following their shock win over the Azzurri.
Defenders Pepe and Joao Cancelo are back for Fernando Santos's side and the coach had all 26 players available for training in advance of the tie at Porto's Estadio de Dragao.
Englishman Anthony Taylor is the referee for the 19:45 BST encounter as Portugal look to make a sixth consecutive appearance in the finals, with North Macedonia attempting to make the huge stage for the first time.