The Reds have reached the last four of the competition for the second consecutive campaign, and will be hoping to go one better this time around, after being knocked out narrowly by Arsenal in last season's semi-finals.
Here’s everything you need to know ahead of another exciting night at Leigh Sports Village...
HOW CAN I FOLLOW THE GAME?
The match will be streamed live on the FA Player, with kick-off taking place at 19:30 GMT. As usual, we’ll be providing updates on our official Twitter account @ManUtdWomen and, after the game, a full match report will be published on ManUtd.