The England international marked his first appearance of the season with a goal at Leicester City on Saturday and, after the game, the manager suggested he was prepared to make changes in a bid to spark an upturn in form.
Although that led to speculation over whether he meant personnel or tactics, the boss has now addressed what he meant in an exclusive interview with club media's Mark Sullivan at Carrington.
One of the burning questions related to whether Rashford would be drafted into the starting line-up against the impressive Serie A side, who currently top Group F on four points.