The Reds have been given some tough tests by the Seagulls but take a great record into the 17:30 BST kick-off at the Amex Stadium.
The run of seven successive victories, in all competitions, should provide confidence for Ralf Rangnick's side ahead of our penultimate assignment of the 2021/22 campaign.
Indeed, Opta have reported that this is our longest ongoing winning run against another current Premier League side.
In the reverse fixture at Old Trafford in February, United won 2-0, thanks to goals from Cristiano Ronaldo and Bruno Fernandes in the second half. The visitors had Lewis Dunk sent off for a foul on Anthony Elanga.