The club has already confirmed that both players are not travelling to Perth, Australia, due to family reasons.
Darmian and Fred will each link up with the squad at a later date.
In case you didn’t know, this is the group that Ole Gunnar Solskjaer has selected…
Goalkeepers: David De Gea, Lee Grant, Joel Pereira, Sergio Romero.
Defenders: Diogo Dalot, Aaron Wan-Bissaka, Eric Bailly, Phil Jones, Victor Lindelof, Marcos Rojo, Chris Smalling, Axel Tuanzebe, Luke Shaw, Ashley Young.
Midfielders: Tahith Chong, James Garner, Angel Gomes, Daniel James, Jesse Lingard, Nemanja Matic, Juan Mata, Scott McTominay, Andreas Pereira, Paul Pogba.