The 20:00 GMT kick-off provides an opportunity for the Reds to return to winning ways after a disappointing run of defeats over the festive period.
Included in our Boxing Day loss at Wolves was a red card for captain Bruno Fernandes and a fifth booking of the campaign for in-form midfielder Manuel Ugarte. Both are thus suspended for the Old Trafford fixture.
Ahead of a night under the lights, we've been playing our United Predictions game alongside MUTV pundits Wes Brown and Danny Webber. Join us in selecting Ruben's starting XI, the scoreline, first goalscorer and your Man of the Match, and you’ll have the chance to win great prizes if you do.