The England centre-back is suspended after picking up a yellow card in Spain, along with Luke Shaw and Scott McTominay, so somebody else will be wearing the captain's armband in the 20:00 BST kick-off.
There are plenty of candidates for the role, with much obviously depending on Ole Gunnar Solskjaer's team selection, so we look at who has taken over the mantle when Harry has been missing in the past.
NEMANJA MATIC
19/9/19 Astana (H) - Europa League
Our experienced Serbian certainly has the know-how and pedigree to be a leading candidate again to stand in for Maguire, as one of the senior figures in the squad.