Although there are matches taking place on Wednesday, and the final games will be played on 7/8 December, with the Reds at home to Young Boys, a picture is already emerging of which clubs we could be paired with when the ceremony takes place on Monday 13 December.
So what lies in store for the boys in the knockout stages, which begin in February 2022?
In addition to United, Ajax, Bayern Munich and Liverpool have already won their groups and will, therefore, be in the same pot for the draw.
Chelsea and Juventus have already qualified, despite the Premier League leaders thumping the Serie A outfit 4-0 at Stamford Bridge on Tuesday night.