The squad is due to fly across the Atlantic in midweek and arrive in Los Angeles, for the opener, against Premier League rivals Arsenal.
The clash with the Gunners is being staged at the SoFi Stadium, with each of the fixtures being shown live to MUTV subscribers.
Kicking off at 17:00 local time on Saturday, UK viewers can watch the action, as it happens, from 01:00 BST on Sunday.
United played Arsenal last year as part of the preparations for the season, winning 2-0 in New Jersey, thanks to goals from Bruno Fernandes and Jadon Sancho.