Another action-packed week for the Reds concludes with a trip to Craven Cottage, with kick-off at the unusual time of 19:00 GMT.
After returning to winning ways against Rangers in the Europa League on Thursday night, we will be looking to complete a league double over Marco Silva’s side by earning another crucial three points.
Ahead of the match under the lights in west London, we’ve been playing our popular United Predictions game alongside MUTV pundit Wes Brown.
Check out his full predictions below before making your own...
BROWN’S PREDICTIONS
United XI
Onana
Yoro
Maguire
Martinez
Amad
Ugarte
Mainoo
Dalot
Fernandes (c)
Garnacho
Zirkzee
First scorer: Bruno Fernandes
Man of the Match: Bruno Fernandes
Result: Fulham 1 United 2
Wes believes Ruben will make four changes from midweek with Andre Onana, Harry Maguire, Manuel Ugarte and Kobbie Mainoo coming back into the side.