Brazil and Argentina are the favourites this time around, while current holders France have also been tipped for success in the Middle East.
United have six players across these three nations at the tournament, as well as 10 other players combined between the squads of Denmark, England, Netherlands, Tunisia, Uruguay and Portugal, with each hoping to lift the iconic trophy on Sunday 18 December - the date of the final.
Ahead of the curtain-raiser between hosts Qatar and Ecuador on Sunday, our writers have offered their thoughts on the Red - or Reds - with the best chance of winning the World Cup this winter.