However, one encounter that will have particular historic significance is United's away trip to Kenilworth Road, to face Luton Town.
The last time the Reds came up against the Hatters in the league was in 1992, just before the Premier League's inception, and since their relegation that year, Luton never returned to the top-flight.
However, in 2022/23, the Bedford-based outfit defeated Coventry City on penalties in the Championship play-off final to complete their fairy-tale nine-year journey from the National League to the Premier League.
What it is does mean is that Kenilworth Road is a destination for each top-flight side in 2023/24, with renovation works already taking place at the home of the Hatters, ensuring it complies with Premier League rules.