Ole Gunnar Solskjaer's side take on Leicester City away at the weekend, and also coming up this week are fixtures for United Women and the Under-23s, Under-21s and Under-18s.
With all of that going on, here's everything you need to know about the next seven days at United...
MONDAY
There'll be continued reaction to France's victory in the UEFA Nations League final over Spain. Raphael Varane, who came off with an injury, joined Paul Pogba in starting the game for Les Bleus, while Anthony Martial was an unused substitute. Later in the day, we'll keep an eye on Ivory Coast's match with Malawi - where Eric Bailly could be involved at 17:00 BST - and a trip to Estonia for Wales, for whom Dylan Levitt could feature in midfield at 19:45 BST.