The Reds are seeking a fourth consecutive Premier League victory, as well as a ninth in a row on the road.
The hosts sit fifth in the table and are in good form themselves under the stewardship of former United boss David Moyes, having beaten Aston Villa, Sheffield United and Fulham in their last three outings.
Fans will be in attendance for the first time in nine months in England's top-flight, with the Hammers permitted 2,000 supporters as London is a Tier 2 area.
Our must-read match preview will provide you with everything you need to know, ahead of another crucial encounter for the Reds.