Wayne Rooney, Michael Carrick and Phil Jones were absent from training ahead of Manchester United's Europa League clash with St Etienne.
Old Trafford plays host to the first leg of the last-32 tie on Thursday night and Jose Mourinho's men are looking to take a comfortable advantage to France next week.
Rooney, Carrick and Jones were noticeably absent from the 23-man squad at the Aon Training Complex on Wednesday morning and will be doubtful for the game against the side currently sitting fifth in Ligue 1.
Jones has been absent since going off in the Premier League match with Hull, due to a foot complaint, but Rooney and Carrick were on the bench against Watford.