The Reds begin our 2021/22 campaign in the Papa John's-sponsored tournament with a tough trip to Lincoln City, with the 19:00 BST kick-off being screened live on MUTV.
Bradford City and Sunderland are also in our group, with the top two sides qualifying for the knockout stages.
United have progressed in both previous seasons in the tournament and scored some fabulous goals along the way, providing excellent entertainment for the supporters.
Take a look at our video compilation of the top 10 United strikes in the competition, which includes efforts by the likes of Ethan Laird, Ethan Galbraith, James Garner, Tahith Chong and Anthony Elanga.