The Reds are looking to book a place in the quarter-final draw, which takes place later this evening.
Following the departure of manager Erik ten Hag, legendary striker van Nistelrooy has taken over the reins and is sure to be warmly greeted by the Old Trafford supporters.
As has been the case of late, there are a couple of question marks over positions but Lisandro Martinez may start at left back, to accommodate Victor Lindelof, while it is not certain which flanks Marcus Rashford and Alejandro Garnacho will operate on.
Altay Bayindir gets another chance to impress in goal, with Andre Onana not in the squad.