The third-round tie will be played at Old Trafford, with admission details to follow as we hope to see a sizeable crowd to cheer the young lads on.
Kick-off is at 19:00 GMT and the game will be covered by MUTV, with clarification over whether this will be live or via highlights to be confirmed in due course after other TV picks are selected by BBC and BT Sport.
Scunthorpe set up the game by beating Shrewsbury Town and Guiseley in previous rounds.
The tie will represent Travis Binnion's first Youth Cup game as lead coach of the side in a competition very dear to the club.