Interim manager Ralf Rangnick has confirmed the latest options for the Selhurst Park showdown, which will be his last in charge before he hands over the reins to Erik ten Hag.
United are currently two points ahead of West Ham United in sixth spot in the table, but with an inferior goal-difference, so only a victory will guarantee a place in next term's Europa League. The Hammers are away to Brighton & Hove Albion on the final day.
There will be a number of players unavailable for the trip to the capital, although Rangnick did not disclose full details at his pre-match press conference.