With the COVID-19 pandemic still affecting large parts of the world, the Reds will be racking up fewer miles than usual, with the first two fixtures taking place in London ahead of Old Trafford hosting the Bees and the Toffees.
And, while remaining in the UK for pre-season has become increasingly rare in the modern game, the agenda for this summer is positively orthodox compared to these six quirky friendlies from the past...
United 4-0 Jonkoping, Polo Grounds, New York, USA, 9 June 1950
This encounter proved a landmark for both sides in that it spanned two separate days.