Tuesday's Premier League game against Nottingham Forest on the opening day of the month is the first of seven fixtures facing Ruben Amorim's men across April, with challenges facing the team at home and abroad.
Of course, the two-legged Europa League quarter-final with French side Lyon is of vital importance, in addition to the league matches on the agenda.
There is plenty to look forward to, including the Manchester derby at Old Trafford, as the domestic game returns with a vengeance.
Check out our brief match-by-match guide...
Tue 1 Apr: Nottingham Forest (A) 20:00 BST
After what feels like an eternity, United are finally back in action when taking on third-placed Nottingham Forest at The City Ground.