The derby with Manchester City will be staged towards the end of the month, with the Old Trafford encounter being moved to 29 October, kicking off at 15:30 GMT. The fixture, which we won 2-1 last season with Marcus Rashford netting a memorable winner, is to be shown live on Sky Sports in the UK.
The unusual start time was agreed following consultation between the clubs, the broadcaster and local authorities.
Our opening league match of this period remains a 15:00 BST kick-off, against Brentford at Old Trafford, with the 7 October date meaning we have a run of four successive home matches in the division in the traditional slot.