Possessing an impressive record against the Villans, the Reds have won all seven previous meetings - an imposing feat that dates back to the early 1900s.
With Ralf Rangnick’s side keen to progress to the next round and continue the club’s dazzling run, here’s a look back at how United arrived at this point…
1906 - United 5 Villa 1
We cruised to a 5-1 victory at our former home Bank Street, thanks to a hat-trick from Jack Picken and a brace from Charlie Sagar. Played in front of a 35,500-strong crowd, Ernest Mangnall’s side would eventually lose in the fourth round, suffering a 3-2 defeat against Arsenal.